Harsha I. Narkhede1, Kanchan M. Khedkr1, Manish M. Patil2, Arshad S. Shaikh2*, Manoj R. Kumbhare1, Umesh B. Gite2,
Prajkta K. Kotkar2
1Department of Pharmaceutical Chemistry SMBT College of Pharmacy, Nandihills, Nashik, India
2Student of Pharmaceutical Chemistry, SMBT College of Pharmacy, Nandihills, Nashik, India
* Address for Correspondence:
Arshad S. Shaikh,
Student of Pharmaceutical Chemistry, SMBT College of Pharmacy, Nandihills, Nashik, India
ORCID: 0009-0005-9708-5526
E-mail: arshdss141@gmail.com
Abstract
These bioactive compounds, such as phenolic, flavonoids, and organosulfur, present in garlic peels have a joint action in providing support to the immune system, metabolic system, neurological system, and cardiovascular system. Although the data so far presented have just been sourced from experimental studies, the information from the molecules discussed in the current review should prompt more research conducted on and involving only the human species. These bioactive compounds in garlic peels could be effective for balancing the redox homeostasis, hence useful for both treatment and prevention in terms of an applied physiological issue. We discuss how these phytochemicals chemically influence antioxidant defense systems, including their action on redox-sensitive signaling pathways, the activation of intrinsic antioxidant enzymes, and the control of reactive oxygen species. The biological activities of bioactive agents in garlic peel preparations on metabolic disease states, neurological processes, inflammatory disease states, and cardiovascular disease states are currently under investigation. The present review aims to reveal to readers the medicinal potential of garlic peel as a functional physiological resource via experimentally collected data from in vitro, in vivo research, and expected extrapolative research. A richer awareness of this agent’s sites of action may prove useful in designing innovative ‘redox-directed’ therapies to prevent and promote health states.
Keywords Garlic peel bioactives; Redox homeostasis; Oxidative stress; Antioxidant signaling pathways; Inflammatory modulation; Applied physiology
